Unlike other tools, with Figma you won't be limited to a single grid at the "artboard" level. Since you can apply a grid to any frame, this means you can apply them to frames that are nested within your design. So feel free to get all Matryoshka on your design and create grids within grids within grids to your hearts content.
Once you begin to leverage this, there are infinite ways to use grids as visual aids within particular areas of your design. You can help differentiate among them by specifying the color and opacity of each grid.